Esters of phosphinylalkanoyl substituted prolines

Details Esters of phosphinylalkanoyl substituted prolines Esters of phosphinylalkanoyl substituted prolines

C - Chemistry, Metallurgy

07

F

260/325.1, 260/3

C07F 9/6561 (2006.01) C07F 9/32 (2006.01) C07F 9/572 (2006.01)

Patent

CA 1196336

ABSTRACT ESTERS OF PHOSPHINYLALKANOYL SUBSTITUTED PROLINES Hypotensive activity is exhibited by new compounds having the formula Image and salts thereof wherein R1 is alkyl, aryl, arylalkyl, cycloalkyl, or cycloalkylalkyl; R2 is cycloalkyl, 3-cyclohexenyl or 2-alkyl- 3-cyclohexenyl; R3 is alkyl, cycloalkyl or phenyl; R4 is hydrogen or alkyl; one of R5 and R6 is hydrogen and the other is alkyl-X-, phenyl-X-, alkoxy, phenyloxy, phenyl, cycloalkyl, alkyl, or phenylalkyl; or together R5 and R6 are -XCH2CH2X-; and X is -S- , Image or Image ; R7 is hydrogen or Image ; and n is 0 or 1.

429206

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