2-dioxacycloalkylthiopenem derivatives

Details 2-dioxacycloalkylthiopenem derivatives 2-dioxacycloalkylthiopenem derivatives

C - Chemistry, Metallurgy

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C07D 499/00 (2006.01) A61K 31/41 (2006.01) C07D 317/24 (2006.01) C07D 317/34 (2006.01) C07D 319/06 (2006.01) C07D 499/88 (2006.01) C07F 7/18 (2006.01)

Patent

CA 1235117

2-DIOXACYCLOALKYLTHIOPENEM DERIVATIVES Abstract Certain 2-dioxacycloalkylthio-2-penem-3-carboxylic acid compounds are useful as antibacterials for treating mammals and have the formula Image ---I or a pharmaceutically acceptable salt thereof, wherein: R is Image A is carbonyl, methylene or thiocarbonyl; B is alkylene having 2-5 carbon atoms; alk is alkylene having 1-6 carbon atoms; R1 is hydrogen or a group which results in an ester which is hydrolyzable in vivo; and n is zero or one.

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