Preparation of a new diosmine derivative

Details Preparation of a new diosmine derivative Preparation of a new diosmine derivative

C - Chemistry, Metallurgy

07

H

260/210

C07H 23/00 (2006.01) A61K 31/70 (2006.01) C07F 5/06 (2006.01) C07H 17/07 (2006.01)

Patent

CA 1318317

ABSTRACT The invention refers to the preparation of diosmine octakis (hydrogen sulfate) aluminium, a new derivative of diosmine, by reaction of diosmine with a sulfating agent, such as sulfur trioxide-pyridine complex, sulfur trioxide-trimethylamine complex and sulfur trioxide-triethylamine complex, at a temperature between 40° and 110°C, in an approprlate medium, with preference pyridine, dimethylformamide and dimethylacetamide, and final addition of aluminium hydroxychloride. This product may be used in gastrointestinal diseases.

573330

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