Substituted thienopyrans as antihypertensive agents

Details Substituted thienopyrans as antihypertensive agents Substituted thienopyrans as antihypertensive agents

C - Chemistry, Metallurgy

07

D

167/207, 260/306

C07D 495/04 (2006.01) A61K 31/38 (2006.01)

Patent

CA 1338419

There are disclosed compounds of the formula: Image wherein Image = Image and R1 and R2 are selected from hydrogen, nitro, cyano, trifluoromethyl, halogen, lower alkyl (C1-4), acyl (C2-4), substituted acyl (C2-4), benzoyl, substituted benzoyl, acylamino (C2-4), alkoxy carbonyl (C1-4), CHO, COOH, CONH2, CON(R)2 and NHCOR wherein R is alkyl (C1-4), alkoxy (C1-4), phenyl or substituted phenyl; R3 and R4 are selected from hydrogen, acyl (C2-5), alkyl (C1-4), cycloalkyl (C3-6), cycloalkyl carbonyl (C3-6), pyridyl carbonyl, benzoyl, substituted benzoyl; or R3R4N together are a heterocyclic pyrrole, pyrrolidine or piperidine ring, a (C3-6) lactam or a glycine anhydride; R5 is hydrogen or together with R6 forms a double bond; R6 is hydrogen, OH, alkoxy (C1-6), acyloxy (C2-7), benzoyl, substituted benzoyl; and R7 and R8 are hydrogen or alkyl (C1-4) or together form a ring having 5-8 carbon atoms. These compounds are useful as antihypertensive agents; antianginals and peripheral antivasoconstrictive agents. The preparation of these compounds and pharmaceutical compositions containing them are also disclosed.

612661

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