Pyrimidone derivatives

Details Pyrimidone derivatives Pyrimidone derivatives

C - Chemistry, Metallurgy

07

D

260/255

C07D 401/14 (2006.01)

Patent

CA 1178960

ABSTRACT The present invention provides compounds of formula (2) :- Image (2) and their pharamaceutaically acceptable salts which are useful as histamine B1-antagonists. In formula (2) R1 is halogen or nitro; R2 is C1-4 alkyl; R3 is a C1-3 alkylene group; and R4 is 3-pyridyl; N-oxo-3- pyridyl; 6-methyl-3-pyridyl; N-oxo-6-methyl-3-pyridyl; 6-hydroxymethyl-3-pyridyl; 4,6-dimethyl-3-pyridyl; N-oxo-4,6-dimethyl-3-pyridyl; 6-hydroxymethyl-4-methyl-3- pyridyl; 5,6-dimethyl-3-pyridyl; N-oxo-5,6-dimethyl-3- pyridyl; 6-hydroxymethyl-5-methyl-3-pyridyl; 4-pyridyl or N-oxo-4-pyridyl.

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