Process for the production and immobilization of modified...

Details Process for the production and immobilization of modified... Process for the production and immobilization of modified...

C - Chemistry, Metallurgy

12

N

195/123, 530/17,

C12N 11/00 (2006.01) C07K 17/00 (2006.01) C12N 9/00 (2006.01) C12N 9/16 (2006.01) C12N 9/38 (2006.01) C12N 11/02 (2006.01) C12N 11/14 (2006.01)

Patent

CA 1200519

ABSTRACT Disclosed is a process for chemically modifying a native protein to produce a biologically active enzyme-like modified protein. In one embodiment, a native protein is partially denatured in the presence of an inhibitor of a model enzyme whose activity is to be modeled. The partially denatured native protein-inhibitor complex is deposited on a solid support and cross-linked to produce a new enzyme-like modified protein. The modified protein shows the enzymatic catalytic behavior characteristic of the model enzyme. - 46 -

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