2-substituted 4-amino-6,7-dimethoxyquinolines

Details 2-substituted 4-amino-6,7-dimethoxyquinolines 2-substituted 4-amino-6,7-dimethoxyquinolines

C - Chemistry, Metallurgy

07

D

167/211, 260/259

C07D 215/42 (2006.01) C07D 215/48 (2006.01) C07D 295/195 (2006.01) C07D 401/00 (2006.01) C07D 401/04 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01)

Patent

CA 1255670

Abstract 2-Substituted 4-Amino-6,7-Dimethoxyquinolines Novel derivatives of 4-amino-6,7-dimethoxyquinoline are disclosed as regulators of the cardiovascular system, in particular as antihypertensive agents, which have the formula: Image where R is a dialkylamino, piperidino or 6,7-dimethoxy-1,2,3,4- tetrahydroisoquinol-2-yl group, or a piperazino group optionally substituted in the 4-position by an alkyl, aryl, aromatic heterocyclyl, acyl, N-substituted carbamoyl or esterified carboxyl group. Preparation of such compounds by cyclisation of N-(1R- substituted-ethylidene)-2-cyano-4,5-dimethoxy-anilines, and by appropriate treatment of the compound in which R is an unsubstituted piperazino group, is described.

433023

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