Naphthothiazepine derivatives and preparation thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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167/209, 260/238

C07D 281/12 (2006.01) A61K 31/55 (2006.01) C07D 281/08 (2006.01)

Patent

CA 1337652

A novel naphthothiazepine derivative of the formula: Image wherein R1 is a lower alkoxy group, R2 is a hydrogen atom or a lower alkanoyl group, and R3 and R4 are the same or different and represent a hydrogen atom or a lower alkyl group, or a pharmaceutically acceptable acid addition salt thereof, are disclosed. Derivatives of the formula (I) and salts thereof are useful as hypotensive agents and/or coronary or cerebral vasodilators.

573506

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