C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/319.3, 260/3
C07D 317/60 (2006.01) C07D 209/20 (2006.01) C07D 209/52 (2006.01)
Patent
CA 1197252
Abstract of the Disclosure A process is provided for the production of compounds of formula Image wherein (II) R1 denotes hydrogen, allyl, vinyl or a side-chain of a naturally occurring .alpha.-aminoacid R1-CH(NH2)-COOH, which may be protected, R2 denotes hydrogen, (C1-C6)-alkyl, (C2-C6)-alkenyl or aryl- (C1-C4)-alkyl, Y denotes hydrogen or hydroxyl and Z denotes hydrogen, and X denotes (C1-C6)-alkyl, (C2-C6)-alkenyl or (C5-C9)-cycloalkyl, or (C6-C12)-aryl, which can be mono-, di- or tri-substituted by (C1-C4)-alkyl, (C1-C4)-alkoxy, hydroxyl, halogen, nitro, amino, (C1-C4)-alkylamino, di-(C1-C4)-alkylamino or methyl- enedioxy, or denotes indol-3-yl. Also provided are products of the formula IV Image when produced by the above-mentioned process, wherein X, R1 and R2 have the above-mentioned meanings, W' denotes a radical which can be split off under basic or acidic conditions or by hydrogenolysis and R2 is not benzyl or nitrobenzyl if W' is benzyl. These compounds are useful starting materials for the preparation of cis, endo- azabicyclo-[3.3.0]-octanecarboxylic acids, which in turn are useful for their long-lasting intense hypotensive action.
459592
Becker Reinhard
Geiger Rolf
Scholkens Bernward
Teetz Volker
Urbach Hansjorg
Aventis Pharma Deutschland Gmbh
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
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