C - Chemistry – Metallurgy – 08 – B
Patent
C - Chemistry, Metallurgy
08
B
195/140, 167/199
C08B 37/08 (2006.01) A61K 8/73 (2006.01) A61K 31/728 (2006.01) A61K 47/36 (2006.01) A61L 15/28 (2006.01) A61L 17/06 (2006.01) A61L 31/00 (2006.01) C08L 5/08 (2006.01)
Patent
CA 1341276
Novel esters of hyaluronic acid of the Formula Hy(COOR)n wherein COO represents the carboxylic acid moiety on the hyaluronic acid (Hy) molecule radical, R is derived from an alcohol which is selected from the group consisting of an aliphatic alcohol having a chain of 2 to 34 carbons, an araliphatic alcohol a cycloaliphatic alcohol or a heterocyclic alcohol, and n is a large number, are provided herein. All or only a portion of the carboxylic groups of the acid are esterified. The salts of the partial esters with metals or with pharmacologically-acceptable organic bases are also provided herein. Pharmaceutical preparation are also provided which contain, as an active ingredient, one or more of the above-described hyaluronic acid esters, or of one or more of the salts thereof. Such pharmaceutical preparation contain a pharmacologically-active substance or an association of pharmacologically-active substances, and a carrying vehicle containing the total or partial esters of hyaluronic acid or salts of such partial esters as described above. The novel esters described above possess bioplastic and pharmaceutical properties and are useful in many fields, including cosmetic surgery and medicine.
513350
Della Valle Francesco
Romeo Aurelio
Fidia S.p.a.
Marcus & Associates
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