Protein pp.sub.9, process for its enrichment and its...

Details Protein pp.sub.9, process for its enrichment and its... Protein pp.sub.9, process for its enrichment and its...

C - Chemistry, Metallurgy

07

K

530/15.12

C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/531 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1187076

NEW PROTEIN PP9, PROCESS FOR ITS ENRICHMENT AND ITS ISOLATION AND ITS USE Abstract of the disclosure: The invention relates to a new protein named PP9 cha- racterized by a) a content of carbohydrates of 5.57 ? 1.35 %, of which are 4.9 ? 1.0 % hexoses, 0.1 ? 0.1 % hexoseamines, 0.07 ? 0.05 % fucose and 0.5 ? 0.20 % neuraminic acid; b) a sedimentation coefficient S20,W of 3.2 ? 0.2 S; c) a molecular weight of 35.100 ? 3.800 determined in the ultracentrifuge; d) a molecular weight of 40.000 ? 4.000 determined in so- dium dodecylsulfate (SDS)-containing polyacrylamide gel; e) an extinction coefficient Image (280 nm) of 14.6 ? 1.0: f) an electrophoretic mobility in the range of the .beta.1- globulins: g) an isoelectric point in a pH range of 5.0 - 6.8 and to a process for its isolation. The protein can be used for the diagnosis of diseases, for following up the course of the diseases and for control of the therapy.

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