Process for the preparation of thieno (2,3-d)- imidazole...

Details Process for the preparation of thieno (2,3-d)- imidazole... Process for the preparation of thieno (2,3-d)- imidazole...

C - Chemistry, Metallurgy

07

D

260/277.7

C07D 495/04 (2006.01)

Patent

CA 1262731

Abstract Process for the preparation of novel derivatives of -thieno(2,3-d)imidazoles of the formula Image I in which R1 denotes hydrogen, lower alkyl, chlorine, bromine, acetyl, cyclopropylcarbonyl, methoxycarbonyl or ethoxycarbonyl, R2 denotes hydrogen or lower alkyl, R3, r5 and R6 independently of one another denote hydrogen or lower alkyl, R4 denotes hydrogen or lower alkoxy and n denotes 0 or 1, and of pharmaceutically acceptable acid addition salts thereof, this process comprising re- acting a compound of the formula Image II with a compound of the formula Image III wherein X represents chlorine or bromine, in the presence of a strong base, and if appropriate partially oxidizing the - 2 - compounds of formula I thus obtained, to give compounds of formula I in which n denotes the number 1. The novel compounds effect a blockade of (H+ + K+)-ATP-ase and can be used for the treatment or prophylaxis of diseases caused by increased gastric secretion.

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