Prostate-derived growth factor

Details Prostate-derived growth factor Prostate-derived growth factor

C - Chemistry, Metallurgy

07

K

530/3.02, 530/15

C07K 14/475 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1332998

The present invention discloses a novel glycoprotein growth factor useful as a mediator of prostatic activities related to abnormal prostatic growth. The novel glycoprotein growth factor is isolated from the prostate gland of rats and has the following characteristics: (a) molecular weight of about 25 kDA as determined by nonreduced sodium dodecylsulfate polyacrylamide gel electrophoresis; (b) sensitivity to reduction by .beta.-mercaptoethanol to form subunits of about 6- 8 kDA with substantial loss of mitogenic activity; (c) isoelectric point of about 5.0 as determined by isoelectric focusing; (d) acid-and heat-stable; (e) unstable to proteolytic action of trypsin and pronase; (f) essentially free of transforming growth factor activity; (g) a defined amino acid composition; and (h) having mitogenic activity against NRK cells.

526589

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