Enzymatic conversion of red cells for transfusions

Details Enzymatic conversion of red cells for transfusions Enzymatic conversion of red cells for transfusions

A - Human Necessities

61

K

167/114, 167/39

A61K 35/18 (2006.01) A01N 1/02 (2006.01) G01N 33/50 (2006.01)

Patent

CA 1168979

ABSTRACT OF THE DISCLOSURE A composition comprising type O erythrocyte free of P1 antigenicity; and a method of converting erythrocytes of the B antigen type to erythrocytes of the H-antigen type which comprises: (A) equilibrating the erythrocytes to a pH of 5.7-5.8; (B) thereafter contacting the so- equilibrated erychrocytes with an enzyme for a period suf- ficient to convert the B antigen in the erythrocytes to the H-antigen; (C) thereafter removing the enzyme from the erythrocytes; and (D) re-equilibrating the erythrocytes to a pH of 7.2-7.4. The preferred enzyme being .alpha.-galactosi- dase. The specification also discloses conversion of the B antigens in human and animal blood to the H antigen (O cells).

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