Laminated composite for transdermal administration of fentanyl

Details Laminated composite for transdermal administration of fentanyl Laminated composite for transdermal administration of fentanyl

A - Human Necessities

61

K

128/104, 167/232

A61K 9/70 (2006.01) A61K 31/445 (2006.01)

Patent

CA 1325381

-12- LAMINATED COMPOSITE FOR TRANSDERMAL ADMINISTRATION OF FENTANYL Abstract of the Disclosure A laminated composite for administering fentanyl transdermally that consists of a fentanyl-impermeable oc- clusive backing layer and an adhesive fentanyl reservoir layer comprising fentanyl dissolved in an amine-resistant polydimethylsiloxane that has a high diffusivity and poor solubility for fentanyl which enables the fentanyl to be released rapidly from the composite over a one day period with little residual fentanyl left in the reservoir there- after.

595816

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