Cyclic anticoagulant peptides

Details Cyclic anticoagulant peptides Cyclic anticoagulant peptides

C - Chemistry, Metallurgy

07

K

530/7.02, 167/10

C07K 14/815 (2006.01) A61K 38/10 (2006.01) A61K 38/58 (2006.01) C07K 7/02 (2006.01) C07K 7/08 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1340646

This invention relates to cyclic peptide derivatives of hirudin of the formula: (see fig. I) which are useful as anticoagulants. The cyclic peptides have a core sequence of approximately 12 amino acids in which there is an intra-cyclized chain that occurs partially through the alkyl chain of a D-amino acid. The modified peptides of this invention also possess significant anticoagulant activity which thereby allows a therapeutically significant adjunct to anticoagulant therapy.

566916

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