Anticoagulant polypeptide

Details Anticoagulant polypeptide Anticoagulant polypeptide

C - Chemistry, Metallurgy

12

N

530/13, 167/103.

C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/47 (2006.01) C07K 14/81 (2006.01) C07K 16/18 (2006.01) C12N 1/21 (2006.01) C12N 15/70 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1338401

A polypeptide having an amino acid sequence as shown in Fig. 1 and its preparation method are disclosed. A DNA fragment capable of coding CPBII polypeptide (human placenta-derived coagulation inhibitor) is first obtained from the human placental cDNA library by using a CPBII-specific antibody as a probe. Then, microorganism cells are transformed by the use of a recombinant plasmid incorporated with the DNA fragment, allowing the resultant transformant to express the CPBII gene, to finally obtain a CPBII-like polypeptide. The polypeptide of this invention exhibits strong anticoagulation activities, and useful for an active component of anticoagulation medicines.

606253

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