Substituted pyridine derivatives

Details Substituted pyridine derivatives Substituted pyridine derivatives

C - Chemistry, Metallurgy

07

D

260/20, 260/296,

C07D 213/55 (2006.01) C07D 213/38 (2006.01) C07D 213/60 (2006.01) C07D 213/79 (2006.01) C07D 473/08 (2006.01) G01N 33/533 (2006.01)

Patent

CA 1276028

ABSTRACT OF THE DISCLOSURE It is disclosed that aryl-substituted 2,6- bis[N,N-di(carboxyalkyl)aminoalkyl] pyridines in which the aryl groups are substituted with one or more elec- tron-releasing groups are an advantageous ligand for forming fluorescent chelates with rare earth metals. The pyridine moieties can be linked to target mole- cules, especially biologically active target molecules to provide fluorescent tagging for use in fluoroassay techniques. The pyridine moieties are disclosed as tetraacids, as salts and as esters. Preparation pro- cesses and precursors including the corresponding aryl-substituted 2,6-dicarboxypyridines as acids, salts and esters, are disclosed as well.

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