Skin permeation enhancer compositions using sucrose esters

A - Human Necessities – 61 – K

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128/104, 167/159

A61K 47/26 (2006.01) A61K 9/70 (2006.01) A61L 15/20 (2006.01)

Patent

CA 1319104

ARC 1427 SKIN PERMEATION ENHANCER COMPOSITIONS USING SUCROSE ESTERS ABSTRACT OF THE DISCLOSURE A method for enhancing the transdermal flux of a transdermally deliverable drug through intact skin is described in which the drug is delivered simultaneously with sucrose monolaurate or a mixture of sucrose esters of coconut fatty acids, which is predominantly sucrose monolaurate. Preferred embodiments of therapeutic systems for delivering the drug and the sucrose ester employ a matrix containing drug at a concentration above saturation.

559834

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