Procedures for preparing composite materials from collagen...

Details Procedures for preparing composite materials from collagen... Procedures for preparing composite materials from collagen...

A - Human Necessities

61

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167/323, 6/50

A61L 15/00 (2006.01) A61L 27/24 (2006.01) A61L 27/26 (2006.01) A61L 31/00 (2006.01) A61L 33/00 (2006.01) A61L 33/12 (2006.01) C08L 89/06 (2006.01) A61F 2/00 (2006.01)

Patent

CA 1197189

PROCEDURES FOR PREPARING COMPOSITE MATERIALS FROM COLLAGEN AND GLYCOSAMINOGLYCAN Abstract This invention relates to crosslinked collagen and glycosaminoglycan materials, and to procedures for preparing such materials. It has been discovered that if collagen fibrils in an aqueous acidic solution are contacted with a crosslinking agent before being contacted with glycosaminoglycan, the materials produced have extremely low levels of thrombogenicity. Such materials are well suited for in-dwelling catheters, blood vessel grafts, and other devices that are in continuous contact with blood for long periods of time.

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