Process for the production of vaccine for prevention of...

Details Process for the production of vaccine for prevention of... Process for the production of vaccine for prevention of...

C - Chemistry, Metallurgy

07

K

167/135, 195/128

C07K 14/285 (2006.01) A61K 39/102 (2006.01) A61K 39/00 (2006.01)

Patent

CA 1316479

17 ABSTRACT OF THE DISCLOSURE JW21 A serum-free vaccine effective against pneumonic pasteurellosis in cattle comprising a non-toxic leukotoxin specific for ruminant leukocytes is disclosed. The leukotoxin is prepared in a serum-free medium from a culture of Pasteurella haemolytica. The produced leukotoxin is harvested from the culture medium upon detecting a certain stage during the logarithmic phase of the cell growth to obtain the optimum concentration of produced cytotoxin in the serum-free medium. Cattle may be treated with the vaccine to develop anti-leukotoxic immunity to pneumonic pasterellosis.

499833

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