Methods for enhancing the contrast in nmr imaging

A - Human Necessities – 61 – K

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324/1, 167/46

A61K 49/00 (2006.01) G01R 33/28 (2006.01)

Patent

CA 1243602

-35- METHODS FOR ENHANCING THE CONTRAST IN NMR IMAGES ABSTRACT Methods for enhancing the contrast of nuclear magnetic images of biological tissues. By contacting the tissues to be imaged with a complex comprising a macromolecule attached to a paramagnetic ion, wherein the macromolecule is tissue specific and the complex has a correlation time of reorientation or a correlation time of rotation of ligands comparable to the Larmor period, thereby altering the proton relaxation rates and enhancing the contrast in the images produced by conventional nuclear magnetic resonance techniques. ??CH-16

461665

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