Process for the preparation of a stable modification of...

C - Chemistry – Metallurgy – 07 – D

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C07D 213/74 (2006.01) A61K 31/44 (2006.01)

Patent

CA 1307277

ABSTRACT Crystalline torasemide in the pure modification I (monoclinic, space group P21/c, melting point 169°C) is prepared from torasemide of modification II (mono- clinic, space group P2/n, melting point 162°C), where- in a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete; pharmaceutical compositions containing the torasemide of modification I have the advantage of stability and ready solubility as compared with modification II; the compositions are of interest as diuretic agents.

515676

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