Production of a-a cross-linked hemoglobins in high yield

Details Production of a-a cross-linked hemoglobins in high yield Production of a-a cross-linked hemoglobins in high yield

C - Chemistry, Metallurgy

07

K

167/114

C07K 14/805 (2006.01)

Patent

CA 1273294

ABSTRACT OF THE DISCLOSURE A high yield method of production of a cross-linked hemoglobin derivative suitable for use as a blood substitute and plasma expander which is cross-linked between Lys 99 Alpha1 and Lys 99 Alpha2 in high percentage by adding the cross-linker in the presence of an added polyanion which blocks competing reactions at other sites of the protein.

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