16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl)...

Details 16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl)... 16-keto-17-substituted thia-17-alkyl (or alkenyl or alkynyl)...

C - Chemistry, Metallurgy

07

J

167/193, 260/28.

C07J 31/00 (2006.01) A61K 31/565 (2006.01)

Patent

CA 1253141

ABSTRACT 16-KETO-17-SUBSTITUTED THIA-17-ALKYL (OR ALKENYL OR ALKYNYL )ANDROSTENES Antiinflammatory activity is exhibited by new steroids having the formula Image and the 1,2-dehydro derivatives thereof, wherein R1 is alkyl, mono-, di- or trifluoroalkyl, R6 Image , aryl or alkylthioalkyl, wherein R6 is alkyl or aryl and m is 1, 2, 3 or 4; R2 is Image wherein R7, R8 and R9 are each independently hydrogen or alkyl of 1 to 4 carbon atoms; R3 is carbonyl or .beta.-hydroxymethylene; R4 is hydrogen or halogen; R5 is hydrogen, methyl or fluorine; and n is 0, 1 or 2; with the proviso that if R1 is alkylthio- alkyl, n is 0.

483357

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