Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-...

Details Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-... Dicarboxylic acid-bis(3,5-dicarbamoyl-2,4,6-...

C - Chemistry, Metallurgy

07

C

167/268, 167/36,

C07C 237/46 (2006.01) A61K 31/165 (2006.01) A61K 31/166 (2006.01) A61K 49/04 (2006.01) C07C 233/00 (2006.01) C07C 233/12 (2006.01)

Patent

CA 1333911

Dicarboxylic acid bis-(3,5-dicarbamoyl-2,4,6- triiodoanilides) of general formula I Image wherein the amide radicals -CONR1R2 and -CONR3R4 are different from one another and R1 is a hydrogen, a lower alkyl radical or R2, R2 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical, R3 is a hydrogen, a lower alkyl radical or R4, R4 is a straight-chain or branched-chain monohydroxy or polyhydroxy alkyl radical, R5 is hydrogen, a lower alkyl radical or a monohydroxy or polyhydroxy alkyl radical, X is a straight-cahin or branched-chain alkylene with 1 to 6 carbon atoms, which optionally can be substituted by 1 to 6 hydroxy or alkoxy groups or interrupted by one or more oxygen atoms, possess good pharmacological and physicochemical properties rendering them outstandingly suitable as radiopaque substances in x-ray contrast media for use in all fields of application for x-ray contrast media.

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