Proteolytic cover of wounds

Details Proteolytic cover of wounds Proteolytic cover of wounds

C - Chemistry, Metallurgy

12

N

167/103.32

C12N 11/12 (2006.01) A61K 38/48 (2006.01) A61L 26/00 (2006.01)

Patent

CA 1217134

ABSTRACT OF THE DISCLOSURE: The invention pertains to a proteolytic cover of wounds in the form of powder, which serves for covering and treatment of ulcerous anc necrotic wounds. It is based on the original combination of the proteolytic and absorption principles of cleaning of infected ulcerous wounds. According to the invention, the cover consists of porous spherical cellulose with particle size 0.05 to 0.5 mm, which contains an immobilized protease. The method of production warrants that the obtained products contain only the covalently bonded protease and no undesirable toxic compounds or soluble por- tions with the proteolytic activity, which could penetrate into blood circulation and develop an alergic reaction as antigens. The immobilized enzymes act in cleaning of the wound by dissolving undesirable proteins, in particular fibrin, necrotic tissues, pus and others. The porous structure of hydrophilic spherical particles of cellulose warrants a high absorption capacity, which is exhibited by sorption of an exudate into the material and suction of pus infected with bacteria from the wound into the inter- particular space of powder layer. The combination of proteolytic and absorption principles enables to achieve the fast cleaning of infected necrotic defects, formation of clean granulations, and fast healing of the wound. The invention may be utilized in pharmaceutical production.

464332

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