N- (5,6,7,8-tetrahydropyrido [2,3-d]...

Details N- (5,6,7,8-tetrahydropyrido [2,3-d]... N- (5,6,7,8-tetrahydropyrido [2,3-d]...

C - Chemistry, Metallurgy

07

D

167/219, 260/242

C07D 471/04 (2006.01) A61K 31/505 (2006.01) C07F 7/10 (2006.01)

Patent

CA 1340631

N-(5,6,7,8-Tetrahydropyrido[2,3-d]pyrimidin-6- yl-alkanoyl)-glutamic acid derivatives are antineoplastic agents which are prepared by removal of amino and/or carboxylic protecting agent. A typical embodiment is N-[5-(2-[2-amino-4-hydroxy-5,6,7,8-tetrahydropyrido[2,3- d]pyrimidin-6-yl]ethyl)thien-2-yl-carbonyl]-L-glutamic acid.

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