Cyclic amides which are leukotriene antagonists

Details Cyclic amides which are leukotriene antagonists Cyclic amides which are leukotriene antagonists

C - Chemistry, Metallurgy

07

D

167/208, 260/305

C07D 401/06 (2006.01) A61K 31/395 (2006.01) C07D 403/06 (2006.01)

Patent

CA 1337202

This invention provides a series of novel cyclic amides of formula I in which the group >Z-Y-X< is selected from >C=CH-N<, >N-CH=CX<, >C=N-N< and >N-N=C< and the other radicals have the meanings defined in the following specification. The compounds of formula I are leukotriene antagonists. The invention also provides pharmaceutically accept- able salts of the formula I compounds; pharmaceutical compositions containing the formula I compound, or their salts, for use in the treatment of, for example, allergic or inflammatory diseases, or endotoxic or traumatic shock conditions; and processes for the manufacture of the formula I compounds, as well as intermediates for use in such manufacture.

596517

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