Fluorescent chelates and labeled specific binding reagents...

Details Fluorescent chelates and labeled specific binding reagents... Fluorescent chelates and labeled specific binding reagents...

C - Chemistry, Metallurgy

07

C

195/35, 260/383,

C07C 65/40 (2006.01) C07C 51/353 (2006.01) C07C 205/45 (2006.01) C07C 335/20 (2006.01) C07D 295/155 (2006.01) C07D 311/16 (2006.01) C07D 471/04 (2006.01) G01N 33/533 (2006.01)

Patent

CA 1205028

ABSTRACT There are described stable fluorescent chelates comprising a complex of a lanthanide metal and chelating agent that includes a nucleus that triplet sensitizer having a triplet energy greater than that of the lanthanide metal and at least two heteroatom-containing groups the form coordinate complexes with lanthanide metals and a third heteroatom-containing group or heteratom in or appended to the triplet sensitizer. Labeled physiologically active materials useful in specific binding assays such as labeled antigens, haptens, antibodies, and hormones, comprising the stable fluorescent labels having physiologically active materials adsorbed or bonded thereto are also described.

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