Process for the preparation of methylene derivatives of...

Details Process for the preparation of methylene derivatives of... Process for the preparation of methylene derivatives of...

C - Chemistry, Metallurgy

07

J

260/39

C07J 1/00 (2006.01)

Patent

CA 1316914

A B S T R A C T The invention relates to a new process for the preparation of known aromatase inhibitors of the following formula Image wherein each of R1 and R3, independently, is hydrogen or C1-C6 alkyl; R2 is hydrogen, halogen or C1-C6 alkyl and R4 is hydrogen or fluorine; the process comprising subjecting to Mannich reaction a compound of formula Image wherein R1,R2,R3 and R4 are as defined above, and then oxidizing the respective 6-methylene derivative thus obtained by methods known per se.

576897

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