Mitomycin analogs

Details Mitomycin analogs Mitomycin analogs

C - Chemistry, Metallurgy

07

D

260/299, 260/298

C07D 487/14 (2006.01)

Patent

CA 1326487

ABSTRACT The present invention provides novel mitomycin analogs containing a cyclic acetal or thioacetal group. These compounds are mitomycin C analogs in which the 7-amino group bears a 5-membered heterocyclic substituent. Mitomycin C is an antitumor agent of established utility, and the 7-N- substituted mitosane analogs thereof have similar utility.

569183

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