C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/34.1, 117/45
C12N 11/00 (2006.01) A61K 9/16 (2006.01) A61K 9/50 (2006.01) B01J 13/02 (2006.01) B01J 13/20 (2006.01) C08K 9/10 (2006.01) C12N 5/00 (2006.01) C12N 11/04 (2006.01) A61K 35/12 (2006.01)
Patent
CA 1184518
Abstract of the Disclosure Disclosed is a process for microencapsulating a core material and subsequently releasing the core material by selectively disrupting the membranes of the microcapsules. The encapsulation technique involves the formation of a semipermeable membrane, e.g., around a droplet, through the formation of multiple ionic salt bonds between a polyionic polymer in the droplet and a crosslinking polyionic polymer which possesses multiple ionic groups of opposite charge. The membrane can be selectively disrupted by exposing it first to a solution of com- peting crosslinking multivalent (preferably di or trivalent) ions followed by a solution of a competing polyionic polymer of the same charge as the polymer in the original droplet. Alternatively, a mixed solution of the two competing solutions may be used together. For example, a membrane comprising anionic alginate salt bonded to cationic protein can be selectively disrupted by exposing the membrane to a mixed solution of mona- tomc, multivalent cations, e.g. Ca++ ions, and a water-scluble polymer have plural anionic moieties, e.g., heparin, and sub- sequently sequestering the monatomic cations. The process may be used to encapsulate and subsequently release cell cultures without damage to the cells.
398210
Damon Corporation
Riches Mckenzie & Herbert Llp
LandOfFree
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