Bisphosphonic acid derivatives, their production and use

Details Bisphosphonic acid derivatives, their production and use Bisphosphonic acid derivatives, their production and use

C - Chemistry, Metallurgy

07

F

167/208, 260/243

C07F 9/653 (2006.01) A61K 31/675 (2006.01) C07F 9/6536 (2006.01) C07F 9/6544 (2006.01)

Patent

CA 1287350

ABSTRACT OF THE DISCLOSURE Novel compounds of Formula I Image (I) or pharmaceutically-acceptable salts thereof, or pharma- ceutically-acceptable in vivo hydrolyzable esters thereof are provided herein. In such Formula, R1-R11 can be the same or different and stand for hydrogen, a straight, branched or cyclic C1-C10 hydrocarbon radical, phenyl or a phenyl-C1-C4-alkyl radical; n is zero or one, and m is zero, one or two; or R2 and R4 when taken together form an unsubstituted saturated aliphatic 5-, 6- or 7- membered ring or a saturated aliphatic 5-, 6- or 7- membered ring which is substituted with one or more C1-C4-alkyl radicals. Such compounds are valuable in human and veterinary practice by reducing bone resorption and surprisingly also in stimulating bone alkaline phosphatase. A substantial increase in bone mass is actually observed during treatment with such compounds.

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