Thieno [2,3-d]azepine derivatives, process for their...

Details Thieno [2,3-d]azepine derivatives, process for their... Thieno [2,3-d]azepine derivatives, process for their...

C - Chemistry, Metallurgy

07

D

167/209, 260/241

C07D 495/04 (2006.01) A61K 31/55 (2006.01)

Patent

CA 1335593

Compounds of the formula Image (I) in which R1 is hydrogen, hydroxy, nitro, cyano, halo, amino, acetamido, hydroxy-C1-4 alkyl, carboxaldehydo, C1-4 alkyl- carbonyl, carboxy, C1-4 alkoxy-carbonyl, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylsulphonyl or C1-4 alkoxy-C1-4 alkyl, R2 is hydrogen, hydroxy, nitro, cyano, halo, amino, carboxamido, acetamido, hydroxy-C1-4alkyl, carboxaldehydo, C1-4 alkylcarbonyl, carboxy, C1-4 alkoxycarbonyl, C1-4 alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkylsulphonyl, C1-4 alkoxy-C1-4 alkyl, oximino or aminomethyl, R3 is optionally substituted phenyl or optionally substituted phenyl ortho condensed with an optionally substituted ring selected from benzene, cyclohexane, cyclohexene, cyclopentane or cyclopentene, in which ring one of the carbon atoms may be replaced by oxygen. sulphur or nitrogen, and R4 is hydrogen, C1-4 alkyl, C2-4 alkenyl or optionally sub- stituted benzyl; and salts thereof; have central nervous system activity.

587930

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