Spontaneous vesiculation of multilamellar liposomes

Details Spontaneous vesiculation of multilamellar liposomes Spontaneous vesiculation of multilamellar liposomes

A - Human Necessities

61

K

167/163

A61K 9/133 (2006.01) A61K 9/127 (2006.01) B01J 13/02 (2006.01)

Patent

CA 1330199

SPONTANEOUS VESICULATION OF MULTILAMELLAR LIPOSOMES ABSTRACT A new method is disclosed for making unilamellar vesicles from multilamellar vesicles. Such vesicles are formed without the use of physical or chemical disruption processes known in the art for forming unilamellar vesicles. The liposomes are incubated at neutral pH at or near the transition temperature of the lipids used, in low ionic strength media such as distilled water. The liposomes may comprise bioactive agents and may be used in vivo or in vitro Lipid compositions are preferably a combination of the phospholipids dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylglycerol (DMPG) in about a 7:3 mole ratio.

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