2,5-diaryl tetrahydrofurans and analogs thereof as paf...

C - Chemistry – Metallurgy – 07 – D

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C07D 307/10 (2006.01) A61K 31/33 (2006.01) C07D 307/12 (2006.01) C07D 307/14 (2006.01) C07D 307/16 (2006.01) C07D 307/18 (2006.01) C07D 307/20 (2006.01) C07D 307/24 (2006.01) C07D 307/34 (2006.01) C07D 405/04 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01) C07D 407/12 (2006.01) C07D 409/14 (2006.01) C07D 417/04 (2006.01)

Patent

CA 1271759

TITLE OF THE DISCLOSURE NEW 2,5-DIARYL TETRAHYDROFURANS AND ANALOGS THEREOF AS PAF ANTAGONISTS ABSTRACT OF THE INVENTION Analogs of 2, 5-Diaryl tetrahydrofurans which were substituted or unsubstituted at 3,4-positions were prepared. These compounds are found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and thereby useful in the treatment of various diseases or disorders mediated by the PAF, for example, hypotension, inflammation, cardio- vasculor disorder, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.

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