Fusion proteins with a eukaryotic ballast portion

Details Fusion proteins with a eukaryotic ballast portion Fusion proteins with a eukaryotic ballast portion

C - Chemistry, Metallurgy

12

N

530/13, 195/1.22

C12N 15/62 (2006.01) C07K 14/535 (2006.01) C07K 14/55 (2006.01) C07K 14/62 (2006.01) C07K 14/815 (2006.01) C07K 19/00 (2006.01) C12N 15/15 (2006.01) C12N 15/17 (2006.01) C12N 15/26 (2006.01) C12P 21/02 (2006.01)

Patent

CA 1339894

A suitable "ballast portion" for fusion proteins is part of the amino acid sequence of interleukin-2 (IL-2) which contains significantly fewer than 100 amino acids. It is advantageous to start from a synthetic IL-2 gene which is divided by unique cleavage sites into six segments, up to three of which can be linked in arbitrary sequence by the modular principle. The invention permits specific constructions with which the solubility of the fusion protein can be altered.

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