Method of determining mimotopes

Details Method of determining mimotopes Method of determining mimotopes

G - Physics

01

N

167/37

G01N 33/53 (2006.01) C07K 7/06 (2006.01) C07K 14/09 (2006.01) C07K 16/10 (2006.01) G01N 33/00 (2006.01) G01N 33/569 (2006.01) G01N 33/68 (2006.01)

Patent

CA 1255586

ABSTRACT OF THE DISCLOSURE A method of detecting or determining the sequence of monomers which is a topological equivalent of the epitope which is complementary to a particular paratope of an antibody of interest, comprises the steps of:- 1. synthesizing a plurality of catamer preparations; each of the catamer preparations consisting of a plurality of catamers in which the composition at one or more designated positions in each catamer is known, and the composition at the remaining positions is randomly made up from members of a defined set of monomers; and the plurality of catamer preparations comprises preparations in which the composition at the designated positions is systematically varied to contain members from a defined set of monomers; 2. contacting each of the plurality of catamer preparations with the antibody of interest; and 3. detecting or determining the presence or absence of binding between each of the plurality of catamer preparations and the given antibody to indicate a partial sequence of the mimotopes for the paratope of the given antibody.

487281

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