C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
195/134, 260/552
C12P 13/02 (2006.01) C12P 13/04 (2006.01) C12P 13/08 (2006.01) C12P 41/00 (2006.01)
Patent
CA 1292434
AE 3631 ABSTRACT The invention relates to a process for racemizing an optically active N-benzylidene amino-acid amide, characterized in that a solution of the N-benzylidene amino-acid amide is mixed in a water-miscible organic solvent with at least 0.05 mole strong base per litre solution. The invention further relates to a process for preparing an L-amino acid by enzymatic separation of the corresponding DL-amino-acid amide with an enzyme preparation from Pseudomonas putida, in which process also unconverted D-amino-acid amide is left behind in solution, characterized in that benzaldehyde is added to the solution, during which addition a precipitate of D-N-benzylidene amino- acid amide is being formed, this precipitate is subsequently, after being separated off, dissolved in an acetone-water mixture, 0.08-0.15 mole KOH/Litre solution is subsequently added, the resulting solution is stirred for 1-20 hours at 20-60°C, sul- phuric acid is then added until the pH of the solution is 5 and the resulting sulphuric acid salt of the DL-amino-acid amide is finally, after isolation at pH 8-10, converted into the DL-amino-acid amide and this DL-amino-acid is used again. 22772-1062
506281
Boesten Wilhelmus H.j.
Dassen Bernardus H.n.
Schoemaker Hans E.
Dsm N.v.
Fetherstonhaugh & Co.
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