3-arylcarbonyl-or 3-cycloalkylcarbonyl-1-(3-amino-2-...

Details 3-arylcarbonyl-or 3-cycloalkylcarbonyl-1-(3-amino-2-... 3-arylcarbonyl-or 3-cycloalkylcarbonyl-1-(3-amino-2-...

C - Chemistry, Metallurgy

07

D

167/208, 260/279

C07D 209/04 (2006.01) C07D 209/08 (2006.01) C07D 209/12 (2006.01) C07D 209/14 (2006.01) C07D 209/30 (2006.01) C07D 401/06 (2006.01) C07D 401/10 (2006.01) C07D 403/06 (2006.01) C07D 403/10 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1255305

22749-319E D.N. 7356B DIV II ABSTRACT OF THE DISCLOSURE Disclosed are novel 3-arylcarbonyl- or 3-cycloalkyl- carbonyl-l-(3-amino-2-hydroxypropyl)-lH-indoles of the formula: Image (Ib) (wherein R2 is hydrogen, alkyl, chloro, optionally substituted phenyl or optionally substituted benzyl, R3 is optionally subs- tituted cyclohexyl, optionally substituted phenyl, optionally substituted styryl, biphenyl, optionally substituted naphthyl, thienyl, furyl, benzothienyl, benzofuryl, quinolyl or N-alkyl pyrrolyl; R4 is hydrogen, alkyl, hydroxy, alkoxy or halo; C=Z is C=O or C=NOH; and N=B is azido, optionally substituted amino or optionally substituted cyclic amino such as morpholinyl, thiomorpholinyl, piperidinyl, pyrrolidinyl, azetidinyl, pipera- zinyl, hexahydrodiazepinyl or the N=B N-oxide thereof) which have analgesic, anti-rheumatic or anti-inflammatory activities and are useful as medicine.

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