1,4-dihydropyridine derivatives having a nitrogen containing...

Details 1,4-dihydropyridine derivatives having a nitrogen containing... 1,4-dihydropyridine derivatives having a nitrogen containing...

C - Chemistry, Metallurgy

07

D

260/277.3, 260/2

C07D 401/06 (2006.01) C07D 211/90 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1310011

H-354/367 Can. - 1 - ABSTRACT The invention concerns the preparation of compounds of formula Image (I) or salts thereof; wherein Ar is an optionally substituted aryl radical; R represents H or an optionally substituted alkyl or aralkyl group; R1 and R2 are the same or different and are selected from H and saturated or unsaturated, cyclic or acyclic aliphatic hydrocarbon residues optionally substituted by one or more groups selected from defined substituents. A represents a group of formula -XR3 wherein X is a group of formula -(CHR6)p-Y-(CHR7)q- or -(CHR6)r-O-(CHR7)? in which formulae: Y represents -S-, NR8 or a direct bond, p and q each represent 0,1 or 2 providing that p and q do not both represent zero when Y is a direct bond; one of r and s represents 0, 1 or 2 and the other is zero; R6, R7 and R8 independently represent hydrogen or lower alkyl, and R3 is an optionally substituted nitrogen ring heteroaryl radical optionally containing other ring heteroatoms selected from O, N or S; B represents hydrogen, carboxyl, lower alkoxycarbonyl, lower alkyl optionally substituted by amino, lower alkoxy,lower alkoxycarbonyl or carboxyl, or amino optionally substituted by one or two lower alkyl groups, which compounds possess antihypertensive and anti- thrombotic activity.

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