Phenyl ketone derivatives as leukotriene antagonists

Details Phenyl ketone derivatives as leukotriene antagonists Phenyl ketone derivatives as leukotriene antagonists

C - Chemistry, Metallurgy

07

C

167/179, 260/247

C07C 59/90 (2006.01) C07C 45/71 (2006.01) C07C 335/32 (2006.01) C07D 257/04 (2006.01) C07D 295/092 (2006.01)

Patent

CA 1242194

Abstract Novel alkane derivatives of the formula (I) Image I or a pharmaceutically acceptable salt thereof, wherein: R1 is hydrogen, C1-C6 alkyl, or C3-C8 cyclo- alkyl; R2 is hydrogen, C1-C6 alkyl, or C2-C6 alkenyl; R3 is hydrogen, C1-C10 alkyl, phenyl, C1-C10 alkyl-substituted phenyl, biphenyl, or benzylphenyl; R4 is -COOR7, -CONR8R9, -CONHOH, -SC(=NH)NH2, cyano, cyanothio, Image where R7 is hydrogen, R8 and R9 are each independently hydrogen, C1-C3 alkyl, or when taken together with the nitrogen atom form a morpholine or N-methyl piperazine ring, R is hydrogen, C1-C4 alkyl, or -CH2COOR7, and p is 0, 1, or 2; R5 and R6 are each independently hydrogen or C1-C3 alkyl; and n is 0-10 are leukotriene antagonists.

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