Psychogeriatric diazinylpiperidine derivatives of cyclic...

Details Psychogeriatric diazinylpiperidine derivatives of cyclic... Psychogeriatric diazinylpiperidine derivatives of cyclic...

C - Chemistry, Metallurgy

07

D

260/259, 260/264

C07D 401/14 (2006.01)

Patent

CA 1272725

PSYCHOGERIATRIC DIAZINYLPIPERIDINE DERIVATIVES OF CYCLIC AMIDES AND IMIDES Abstract of the Disclosure A series of nootropic compounds of Formula I Image I wherein X is an ethylene chain or a 1,2-benzo ring; Y is carbonyl or methylene; R1 is hydrogen or lower alkyl; and z is an R2, R3-disubstituted diazinyl ring selected from pyridazine, pyrimidine, and pyrazine ring systems. Pharmacological testing demonstrates that the series possesses ability to reverse ECS-induced amnesia in a step-down passive avoidance response test. These pharmacological test results indicate that compounds of Formula I possess cognition and memory enhancing activity.

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