C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
195/1.33, 167/10
C12N 15/58 (2006.01) A61K 9/00 (2006.01) A61K 38/49 (2006.01) C12N 5/10 (2006.01) C12N 9/72 (2006.01) C12N 15/63 (2006.01) C12P 21/02 (2006.01)
Patent
CA 1341580
Biologically active mutant tissue plasminogen activators are disclosed wherein site directed mutagenesis, for example, of a two-chain activation site renders said mutants resistant to conversion to the two-chain form.
507294
Heyneker Herbert Louis
Vehar Gordon Lallen
Dennison Associates
Genentech Inc.
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