Indium-bleomycin complex ( suniii xxin-blmc)

Details Indium-bleomycin complex ( suniii xxin-blmc) Indium-bleomycin complex ( suniii xxin-blmc)

C - Chemistry, Metallurgy

07

K

167/47, 530/9

C07K 9/00 (2006.01) A61K 49/02 (1985.01)

Patent

CA 1253300

-1- Abstract A new 111In-BLM complex designated 111In-BLMC is described. The complex is characterized by a lack of capacity for binding to serum transferrin, a high selective affinity for viable tumor tissue, in vivo stability, improved activity ratios of tumor to tissues over known 111In-BLM complexes, tumor imaging flexi- bility and distinctness, and rapid clearance from the body. The new 111In-BLM Complex thus has clinical use as a radiopharmaceutical for combining radiotherapy and chemotherapy, and as a tumor-imaging agent for diagno- sis.

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