C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/314
C07D 233/64 (2006.01)
Patent
CA 1280424
ABSTRACT OF THE DISCLOSURE A process for the preparation of modification A of cimetidine (N- cyano-N' -methyl- N" -(2-/(5-methylimidazole-4- yl)methylthio/ethyl]guanidine} from cimetidine H (or, with another name, cimetidine M-i) which comprises treating cimetidine H in a fluidized or mixed state with a gas flow of a temperature between 70°C and 110°C under continuous maintenance of the crystalline state. The modification A of cimetidine is an excellent histamine H2 receptor blocking agent and can be used for treating ulcer.
546508
Gorog Sandor
Harsanyi Kalman
Hegedus Bela
Horvath Zoltan
Marks & Clerk
Richter Gedeon Vegyeszeti Gyar Rt.
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