Process and intermediates for the preparation of penem...

C - Chemistry – Metallurgy – 07 – D

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C07D 205/08 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07D 499/00 (2006.01) C07D 499/86 (2006.01)

Patent

CA 1252096

PROCESS AND INTERMEDIATES FOR THE PREPARATION OF PENEM DERIVATIVES Abstract Certain substituted-2-penem-3-carboxylic acid compounds, and pharmaceutically-acceptable salts thereof, can be prepared from the appropriate xanthate or trithiocarbonate by desulfurization, followed by halogenation and ring closure. The corresponding desulfurized and halogenated intermediates are disclosed.

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