Arg-serpin human plasminogen activator inhibitor designated...

Details Arg-serpin human plasminogen activator inhibitor designated... Arg-serpin human plasminogen activator inhibitor designated...

C - Chemistry, Metallurgy

12

N

195/1.22, 195/1.

C12N 15/15 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1341339

The invention is directed to an Arg-Serpin human plasminogen activator inhibitor designated PAI-2. This protein is prepared via recombinant DNA means. The invention also includes other serpins which can be made by amino acid substitutions or deletions in conserved regions of PAI-1 and PAI-2. The proteins of the invention can be used to inhibit, or at least modulate, human plasminogen activator activity in a variety of physiological conditions, e.g., fibrinolysis, tumor metastasis, and tumor growth.

556827

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