Poly(glycolic acid/poly(oxyethylene)triblock copolymers and...

C - Chemistry – Metallurgy – 08 – G

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400/2015, 400/20

C08G 63/08 (2006.01) A61K 9/20 (2006.01) A61L 17/00 (2006.01) A61L 17/12 (2006.01) A61L 27/18 (2006.01) A61L 31/06 (2006.01) C08G 63/664 (2006.01)

Patent

CA 1213089

POLY(GLYCOLIC ACID)/POLY(OXYETHYLENE)TRIBLOCK COPOLYMERS AND METHOD OF MANUFACTURING THE SAME ABSTRACT OF THE DISCLOSURE Poly(glycolic acid)poly(oxyethylene) ABA triblock co- polymers having the following formula: Image wherein R represents an alkylene, x is about 37.5 to 47.5, and y is about 5 to 25, weight percent. The copolymers are useful for manufacturing fibers possessing a sufficiently low modulus of elasticity to permit their use as absorbable sutures having the requisite flexibility for use in monofilament form. A process of preparation involves purifying the hydroxyl-ended poly(oxyalkyl- ene) and allowing it to react with glycolide to produce an ABA triblock copolymer of extrusion grade in which A represents a polyglycolic acid block and B represents a poly(oxyalkylene) block.

440969

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